NAD+ / MOTS-c / 5-Amino-1MQ Peptide Blend Description
The BioLongevity Labs NAD+/MOTS-c/5-Amino-1MQ Blend unites three distinct compounds that converge on cellular energy, mitochondrial function, and metabolic regulation:
- NAD+ (100 mg) replenishes the central redox cofactor required for metabolism, DNA repair, and sirtuin activation [1][2][3].
- MOTS-c (10 mg) is a mitochondria-derived peptide that activates AMPK, regulates nuclear gene expression under metabolic stress, and enhances insulin sensitivity [4][5][6].
- 5-Amino-1MQ (10 mg) inhibits NNMT, raising NAD+ levels while modulating histone methylation and fat metabolism pathways [7][8][9].
Together, their mechanisms are designed to:
- Enhance mitochondrial and cellular energy balance by restoring NAD+ pools and activating AMPK [1][4][7].
- Improve metabolic health by reducing adiposity, sustaining muscle function, and optimizing glucose regulation [2][5][8].
- Support cognitive and longevity research through effects on neuroinflammation, oxidative stress, and cellular senescence [3][6][9].
Peptide Structures
NAD+ (Nicotinamide Adenine Dinucleotide)
- Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
- Molecular Weight: 663.43 g/mol
- PubChem CID: 925
- CAS Number: 53-84-9
- Synonyms: β-Nicotinamide adenine dinucleotide, DPN, Coenzyme I, Diphosphopyridine nucleotide
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: 2174.6 g/mol
- PubChem SID: 255386757
- CAS Number: 1627580-64-6
- Synonyms: Human MOTS-c, UNII-A5CV6JFB78, MOTS-c trifluoroacetate salt
5-Amino-1MQ (5-Amino-1-methylquinolinium)
- Molecular Formula: C₁₀H₁₁N₂
- Molecular Weight: 159.21 g/mol
- PubChem CID: 950107
- CAS Number: —
- Synonyms: 5-amino-1-methylquinolinium, SCHEMBL6403148, CHEMBL4116828, ZMJBCEIHNOWCMC-UHFFFAOYSA-O, STL196667
This synergistic triad provides a unique investigational platform for metabolism, neuroprotection, and healthy aging research.
Blend Structure
| Ingredient | Dose (per capsule) | Key Actions |
| NAD+ | 100 mg | Cofactor in redox metabolism; activates sirtuins & AMPK; supports DNA repair & mitochondrial biogenesis [1][2][3] |
| MOTS-c | 10 mg | Mitochondria-encoded peptide; AMPK activation; improves insulin sensitivity; prevents metabolic dysfunction [4][5][6] |
| 5-Amino-1MQ | 10 mg | NNMT inhibitor; ↑NAD+; ↓adiposity; epigenetic modulation; metabolic & oncology research [7][8][9] |
Research Areas
- Cellular Energy & Mitochondrial Function
- Metabolic Regulation & Obesity Research
- Muscle Preservation & Physical Performance
- Neuroprotection & Cognitive Function
- Longevity & Anti-Aging Mechanisms
- Preclinical Cancer Research